In 1978, she graduated from the FMDU and was recruited as a lecturer at the Department of Histology FMDU. In 1988 and 1990 she joined a cytogenetics course in Tottory University Japan and started working as a supervisor of the cytogenetic unit at Telogorejo Hospital.
In 1992, she went to Sydney, Australia for training in cancer cytogenetics at the Prince of Wales Hospital, followed by her PhD on Medical Genetics (1994-1998) at the UNSW, during which she did her course on Clinical Genetics at Sydney Children Hospital (1994-1995), Clinical epidemiology at School of Community Medicine, UNSW Sydney (1995), Molecular Genetics at DNA Research Laboratory, Ongwanada Resource Centre and Queen’s University Kingston Canada (1996 and 1997). In 1999, she started working as the Head of Molecular and Cytogenetics Unit, Medical Biotechnology Laboratory FMDU, lecturer in medical genetics for postgraduate students at the same university, and genetic counselor at Telogorejo Hospital. In 2000, she awarded a Scientific Article Writing Program from the Directorate of Higher Education, Indonesia for her research on Molecular screening for fragile-X mental retardation syndrome (Am J Med Genet. 1999). She presented and published her research in national and international conferences and journals. She attended many other short courses such as at AMC Hospital, Amsterdam (2000), the Department of Human Genetics, RUNMC Nijmegen (2000) and the Medical Investigation for Neurodevelopmental Disorders Institute at the University of California, Davis (2002). She is a member of the American Society of Human Genetics and Human Genetics Australia since 1994.
In 2003, she has been appointed as a professor of medical science. Since 2005 she is a member of National Research Council. In 2005, she awarded the best lecturer at MFDU. In 2006, she initiates an establishment of Magister of Genetic Counselling program, which is the first genetic counseling course in Indonesia and also in ASEAN country. Since 2007 she has appointed as a director of Center for Biomedical Research (Cebior), a new name for Biotechnology Laboratory at Faculty of Medicine Diponegoro University. Since 2008 she became a member of Human Genome Project (HUGO). In 2008 she awarded a best scientist as the founder of genetic laboratory in Central Java from the Mayor of Semarang Municipality and in 2009 awarded Australian Alumni Finalist in Research and Innovation from the Australian Embassy in Jakarta.
In 2010 she awarded a fellowship for academic recharging program at Murdoch Children Research Institute/ University of Melbourne for 3 months. She has appointed as a vice Rector for development and collaboration since January 2011.